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Article

Functional interplay between dual site phospholambam phosphorylation: insights from genetically altered mouse models.

Basic research in cardiology - 1 Jan 2002

Chu Guoxiang, Kranias Evangelia G

Abstract excerpt

Dephosphorylated phospholamban (PLB) is an inhibitor of the affinity of the sarcoplasmic reticulum (SR) Ca2+ pump (SERCA2) for Ca2+. Phosphorylation of PLB relieves its inhibitory effects on SERCA2, with subsequent acceleration of Ca2+ transport into the SR lumen, which has been suggested to underlie the positive inotropic and lusitropic actions of beta-adrenergic agonists in the mammalian heart. PLB can be...

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Calcium-Binding Proteins
Heart
Mice
Mice, Knockout
Myocardium
Phosphorylation

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PMID: 12479233
DOI: 10.1007/s003950200028

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