Article
Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis.
Arthritis and rheumatism - 1 Mar 2003
Tsui Florence W L, Tsui Hing Wo, Cheng Emily Y, Stone Millicent, Payne Ursula, Reveille John D, Shulman Marc J, Paterson Andrew D, Inman Robert D
Abstract excerpt
OBJECTIVE: To use a candidate gene approach for the identification of genetic markers that are significantly linked to and associated with ankylosing spondylitis (AS). METHODS: We searched for novel polymorphisms in the ANKH gene (human homolog of the murine progressive ankylosis gene) and genotyped 2 polymorphic sites, one in the 5'-noncoding region and the other in the promoter region of ANKH, using DNA from...
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