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Article

Investigation of the role of ANKH in ankylosing spondylitis.

Arthritis and rheumatism - 1 Oct 2003

Timms A E, Zhang Y, Bradbury L, Wordsworth B P, Brown M A

Abstract excerpt

OBJECTIVE: The ank/ank mouse develops a phenotype similar to ankylosing spondylitis (AS) in humans. ANKH, the human homolog of the mutated gene in the ank/ank mouse, has been implicated in familial autosomal-dominant chondrocalcinosis and autosomal-dominant craniometaphyseal dysplasia. This study was undertaken to investigate the role of ANKH in susceptibility to and clinical manifestations of AS. METHODS:...

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Share to Spondylitis, Ankylosing
Share to Gene Frequency
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Membrane Proteins

Share to Phosphate Transport Proteins

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 14558096
DOI: 10.1002/art.11258

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Investigation of the role of ANKH in ankylosing spondylitis.PMID 14558096Read ↗

Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis.Semantic proximity Read ↗

ANKH and susceptibility to and severity of ankylosing spondylitis.Semantic proximity Read ↗

ANKH variants associated with ankylosing spondylitis: gender differences.Semantic proximity Read ↗

Novel ANKH mutation in a patient with sporadic craniometaphyseal dysplasia.Semantic proximity Read ↗

Autosomal recessive mental retardation, deafness, ankylosis, and mild hypophosphatemia associated with a novel ANKH mutation in a consanguineous family.Semantic proximity Read ↗

Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.Semantic proximity Read ↗

HLA-B27 has no effect on the phenotypic expression of progressive ankylosis in ank/ank mice.Semantic proximity Read ↗

Biochemical and genetic analysis of ANK in arthritis and bone disease.Semantic proximity Read ↗

Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene.Semantic proximity Read ↗

Mineral formation in joints caused by complete or joint-specific loss of ANK function.Semantic proximity Read ↗

Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis.Semantic proximity Read ↗

Mutations in ANKH cause chondrocalcinosis.Semantic proximity Read ↗

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