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Article

ANKH and susceptibility to and severity of ankylosing spondylitis.

The Journal of rheumatology - 1 Jan 2012

Pimentel-Santos Fernando Manuel, Ligeiro Dario, Matos Mafalda, Mourão Ana Filipa, Vieira de Sousa Elsa, Pinto Patricia, Ribeiro Ana, Santos Helena, Barcelos Anabela, Godinho Fatima, Cruz Margarida, Fonseca Joao Eurico, Guedes-Pinto Henrique, Trindade Helder, Brown Matthew A, Branco Jaime C

Abstract excerpt

OBJECTIVE: Unconfirmed reports describe association of ankylosing spondylitis (AS) with several candidate genes including ANKH. Cellular export of inorganic pyrophosphate is regulated by the ANK protein, and mutant mice (ank/ank), which have a premature stop codon in the 3' end of the ank gene, develop severe ankylosis. We tested the association between single-nucleotide polymorphisms (SNP) in these genes and...

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Source

Identifiers

PMID: 22089454
DOI: 10.3899/jrheum.110681

Genes

ANKH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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ANKH and susceptibility to and severity of ankylosing spondylitis.PMID 22089454Read ↗

Investigation of the role of ANKH in ankylosing spondylitis.Semantic proximity Read ↗

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Is disease severity in ankylosing spondylitis genetically determined?Semantic proximity Read ↗

Identification of major loci controlling clinical manifestations of ankylosing spondylitis.Semantic proximity Read ↗

Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis.Semantic proximity Read ↗

Association study of genes related to bone formation and resorption and the extent of radiographic change in ankylosing spondylitis.Semantic proximity Read ↗

Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.Semantic proximity Read ↗

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis.Semantic proximity Read ↗

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