Article
Pathogenic variants screening in seventeen candidate genes on 2p15 for association with ankylosing spondylitis in a Han Chinese population.
PloS one - 1 Jan 2017
Wang Mengmeng, Xin Lihong, Cai Guoqi, Zhang Xu, Yang Xiao, Li Xiaona, Xia Qing, Wang Li, Xu Shengqian, Xu Jianhua, Shuai Zongwen, Ding Changhai, Pan Faming
Abstract excerpt
OBJECTIVES: Previous studies have found the association between rs10865331 in 2p15 area and ankylosing spondylitis (AS). This study aimed to identify additional functional genetic variants in 2p15 region associated with AS susceptibility. METHODS: We used next generation sequencing (NGS) in 100 AS cases and 100 healthy controls to screen AS susceptible genetic variants, and validated these variants in 620 cases...
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