Article
Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Sept 2014
Huang Pauline Y, Best Oliver G, Almazi Juhura G, Belov Larissa, Davis Zadie A, Majid Aneela, Dyer Martin J, Pascovici Dana, Mulligan Stephen P, Christopherson Richard I
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is clinically heterogeneous. While some patients have indolent disease for many years, 20-30% will progress and ultimately die of their disease. CLL may be classified by the Rai or Binet staging system, mutational status of the immunoglobulin variable heavy-chain gene (IGVH), ZAP-70 overexpression, cytogenetic abnormalities (13q-, + 12, 11q-, 17p-) and expression of several cell...
Topics
- Antigens, Surface
- B-Lymphocytes
- Cluster Analysis
- Disease Progression
- Humans
- Immunophenotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Phenotype
- Prognosis
- Reproducibility of Results