Article
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Cell - 7 Mar 2003
Yajnik Vijay, Paulding Charles, Sordella Raffaella, McClatchey Andrea I, Saito Mako, Wahrer Doke C R, Reynolds Paul, Bell Daphne W, Lake Robert, van den Heuvel Sander, Settleman Jeff, Haber Daniel A
Abstract excerpt
We used representational difference analysis to identify homozygous genomic deletions selected during tumor progression in the mouse NF2 and TP53 tumor model. We describe a deletion targeting DOCK4, a member of the CDM gene family encoding regulators of small GTPases. DOCK4 specifically activates Rap GTPase, enhancing the formation of adherens junctions. DOCK4 mutations are present in a subset of human cancer...
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