Article
The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2011
Kawasaki Fumiko, Iyer Janani, Posey Lisa L, Sun Chichun E, Mammen Samantha E, Yan Huaru, Ordway Richard W
Abstract excerpt
Members of the DISABLED (DAB) family of proteins are known to play a conserved role in endocytic trafficking of cell surface receptors by functioning as monomeric CLATHRIN-associated sorting proteins that recruit cargo proteins into endocytic vesicles. Here, we report a Drosophila disabled mutant revealing a novel role for DAB proteins in chemical synaptic transmission. This mutant exhibits impaired synaptic...
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