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Article

In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading.

Nature genetics - 1 Apr 2003

Knight Julian C, Keating Brendan J, Rockett Kirk A, Kwiatkowski Dominic P

Abstract excerpt

In vivo characterization of regulatory polymorphisms is a key requirement for next-generation human genetic analysis. Here we describe haploChIP, a method that uses chromatin immunoprecipitation (ChIP) and mass spectrometry to identify differential protein-DNA binding in vivo associated with allelic variants of a gene. We demonstrate this approach with the imprinted gene SNRPN. HaploChIP showed close correlation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12627232
DOI: 10.1038/ng1124

Genes

LTA
SNRPN
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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