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Article

Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers.

Journal of occupational and environmental medicine - 1 Feb 2003

Lee Burton W, London Leslie, Paulauskis Joseph, Myers Jonny, Christiani David C

Abstract excerpt

Pesticides, such as parathion, are metabolized by cytochrome p-450 system to paraoxon, which is a potent cholinesterase inhibitor. Paraoxonase (PON) catalyzes the hydrolysis of these toxic metabolites and protects against pesticide toxicity. A glutamine/arginine (Gln/Arg) polymorphism at amino acid position 192 of PON has been described. The Arg/Arg genotype is associated with higher serum paraoxonase activity...

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Source

Identifiers

PMID: 12625227
DOI: 10.1097/01.jom.0000052953.59271.e1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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