Article
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
Science (New York, N.Y.) - 7 Mar 2003
Libby Richard T, Smith Richard S, Savinova Olga V, Zabaleta Adriana, Martin Janice E, Gonzalez Frank J, John Simon W M
Abstract excerpt
Mutations in the cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a common cause of human primary congenital glaucoma (PCG). Here we show that Cyp1b1-/- mice have ocular drainage structure abnormalities resembling those reported in human PCG patients. Using Cyp1b1-/- mice, we identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype, with Tyr deficiency...
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