Article
The morphogen behind primary congenital glaucoma and the dream of targeting.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie - 1 Jan 2017
Shohdy Kyrillus Samaan, Rashad Wegdan Aly, Fargoun Mohamed Khalid, Urban Phillippe
Abstract excerpt
Glaucoma is a clinical entity with multifactorial etiology, a severe subtype occurs in infancy called primary congenital glaucoma (PCG). Three distinct levels interact sequentially to produce PCG: (i) genetic mutations mainly affecting the CYP1B1 gene, (ii) absence or dysregulation of a morphogen, and (iii) trabecular meshwork pathological changes either in patterning or remodeling. We will discuss these three...
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