Article
Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes.
Pharmacogenetics - 1 Oct 1998
Takahashi H, Kashima T, Nomoto S, Iwade K, Tainaka H, Shimizu T, Nomizo Y, Muramoto N, Kimura S, Echizen H
Abstract excerpt
To study whether an in-vitro model for three different genotypes of human CYP2C9*3 polymorphism would be useful for predicting the in-vivo kinetics of (S)-warfarin in patients with the corresponding genotypes, the intrinsic clearance (Cl(int) or Vmax/Km) for (S)-warfarin 7-hydroxylation obtained...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Anticoagulants
- Aryl Hydrocarbon Hydroxylases
- Child
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 Enzyme System
- Female
- Heart Valve Prosthesis Implantation
- Humans
- Hydroxylation
- Leucine