Article
T(-786)→C polymorphism of the endothelial nitric oxide synthase gene is associated with insulin resistance in patients with ischemic or non ischemic cardiomyopathy.
BMC medical genetics - 2 Oct 2012
Vecoli Cecilia, Andreassi Maria Grazia, Liga Riccardo, Colombo Maria Giovanna, Coceani Michele, Carpeggiani Clara, L'Abbate Antonio, Neglia Danilo
Abstract excerpt
BACKGROUND: Insulin resistance (IR) and endothelial dysfunction are frequently associated in cardiac disease. The T(-786)→C variant in the promoter region of the endothelial nitric oxide synthase (eNOS) gene has been associated with IR in both non-diabetic and diabetic subjects. Aim of the study was to assess the reciprocal relationships between T(-786)→C eNOS polymorphism and IR in ischemic and non-ischemic...
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