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Article

Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population.

Journal of biomedical science - 5 Dec 2012

Chan Shih-Hung, Chen Jyh-Hong, Li Yi-Heng, Tsai Liang-Miin

Abstract excerpt

BACKGROUND: Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we hypothesize that Gly1057Asp polymorphism in IRS-2 is associated with CAD. METHODS: Patients receiving elective coronary angiography were enrolled. Significant stenosis is defined as a luminal...

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Identifiers

PMID: 23216712
DOI: 10.1186/1423-0127-19-100
PMCID: PMC3541354

Genes

CAD

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