Article
Primordial germ cells, stem cells and testicular cancer.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 1998
Donovan P J, de Miguel M, Cheng L, Resnick J L
Abstract excerpt
Primordial Germ Cells (PGCs) arise in the mouse embryo as a small population of cells some way from the gonad anlagen. In order for the embryo to develop into a fully fertile adult animal the PGCs must increase in number and reach the gonad. Mutations causing sterility in the mouse have identified some of the genes involved in regulating PGC development and some of these genes have been molecularly cloned....
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