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Article

Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation

26 Nov 2014

Abstract excerpt

As complete absence of germ cells leads to sterile males in zebrafish, we explored the relationship between primordial germ cell (PGC) number and sexual development. Our results revealed dimorphic proliferation of PGCs in the early zebrafish larvae, marking the beginning of sexual differentiation. We applied morpholino-based gene knockdown and cell transplantation strategies to demonstrate that a threshold number...

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PMID: 25434820
DOI: 10.1016/j.stemcr.2014.10.011

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