Article
Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression.
Cardiovascular research - 1 Mar 2003
Ashton Kevin J, Holmgren Kirsty, Peart Jason, Lankford Amy R, Paul Matherne G, Grimmond Sean, Headrick John P
Abstract excerpt
OBJECTIVES: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A(1) adenosine receptors (A(1)ARs). METHODS: cDNA microarrays were used to explore expression of 1824 genes in wild-type hearts and ischemia-tolerant mouse hearts overexpressing A(1)ARs. RESULTS: Overexpression of A(1)ARs reduced post-ischemic contractile...
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