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Article

Human Papilloma Virus Does Not Fully Inactivate p53 Cellular Activity in HNSCC.

Head & neck - 1 Mar 2026

Gencel-Augusto Jovanka, Li Hua, Woerner Liam C, Tian Nuo, Borah Ashir A, Myers Jeffrey N, Ha Patrick, Johnson Daniel E, Grandis Jennifer R

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a major global health challenge. Inactivation of the tumor suppressor p53 is the most frequent driver event in this malignancy. p53 inactivation occurs either through TP53 mutations in human papilloma virus (HPV)-negative cases or via HPV-mediated p53 degradation in HPV-positive (HPV+) cases, where most tumors retain a wild-type (WT) TP53 allele. This underscores...

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Share to Papillomaviridae
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Head and Neck Neoplasms

Share to Human Papillomavirus Viruses

Share to Papillomavirus Infections

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 41168931
DOI: 10.1002/hed.70085
PMCID: PMC12626247

Genes

TP53
INPP5D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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