Pax6 regulates regional development and neuronal migration in the cerebral cortex.

doi:10.1016/s0012-1606(02)00046-5

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Article

Pax6 regulates regional development and neuronal migration in the cerebral cortex.

Developmental biology - 1 Mar 2003

Talamillo Ana, Quinn Jane C, Collinson J Martin, Caric Damira, Price David J, West John D, Hill Robert E

Abstract excerpt

Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of wild-type and Pax6-deficient cells. The chimeric analysis shows that Pax6 influences cellular...

Topics

Animals
Cell Movement
Cerebral Cortex
Chimera
Crosses, Genetic
Eye Proteins
Female
Gene Expression Regulation, Developmental
Genotype
Homeodomain Proteins
Homozygote
Male
Mice
Mice, Inbred A

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Mutant Strains

Mutation

Neurons

Source

Open in PubMed

Identifiers

PMID: 12618140
DOI: 10.1016/s0012-1606(02)00046-5

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