Article
Effects of CYP2D6 genotypes on plasma concentrations of risperidone and enantiomers of 9-hydroxyrisperidone in Japanese patients with schizophrenia.
Journal of clinical pharmacology - 1 Feb 2003
Yasui-Furukori Norio, Mihara Kazuo, Kondo Tsuyoshi, Kubota Takahiro, Iga Tatsuji, Takarada Yutaka, De Vries Ronald, Kaneko Sunao, Tateishi Tomonori
Abstract excerpt
It has been shown that risperidone (+)-9-hydroxylation is enantioselectively catalyzed by the polymorphic CYP2D6 in human liver. This study aimed to examine the effect of CYP2D6 genotype on (+)-9-hydroxylation of risperidone in schizophrenic patients. Subjects were 38 Japanese schizophrenic inpatients receiving 6 mg/day of risperidone. Plasma concentrations of risperidone and (+)- and (-)-9-hydroxyrisperidone at...
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