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Article

Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes.

British journal of clinical pharmacology - 1 May 2004

Yasui-Furukori Norio, Mihara Kazuo, Takahata Takenori, Suzuki Akihito, Nakagami Taku, De Vries Ronald, Tateishi Tomonori, Kondo Tsuyoshi, Kaneko Sunao

Abstract excerpt

AIMS: An in vitro study has suggested that risperidone is a substrate of P-glycoprotein, which is coded by MDR-1 gene. Thus, we studied the effects of major polymorphisms of the MDR-1 gene on plasma drug concentrations. METHODS: Subjects were 85 schizophrenic patients receiving 3 mg twice daily o...

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Identifiers

PMID: 15089809
DOI: 10.1111/j.1365-2125.2003.02061.x
PMCID: PMC1884506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15089809-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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