Article
Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients.
European journal of clinical pharmacology - 1 Nov 2001
Roh H K, Kim C E, Chung W G, Park C S, Svensson J O, Bertilsson L
Abstract excerpt
OBJECTIVE: Risperidone is known to be biotransformed to its active metabolite, 9-hydroxyrisperidone, by the polymorphic CYP2D6 in Caucasians. This study aimed to investigate the relationship between the CYP2D6*10 allele and the plasma levels of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients. METHODS: Eighty-two Korean schizophrenic patients in monotherapy with oral doses of risperidone from...
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