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Article

A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 9 Oct 2010

Locatelli Igor, Kastelic Matej, Koprivsek Jure, Kores-Plesnicar Blanka, Mrhar Ales, Dolzan Vita, Grabnar Iztok

Abstract excerpt

The objective of this prospective study was to characterize the metabolism of risperidone to (+)- and (-)-9-hydroxyrisperidone in vivo and to evaluate the influence of CYP2D6 genotype. A population pharmacokinetic modeling approach was used to estimate the interindividual variability of the pharmacokinetic parameters in 50 hospitalized patients with acute episode of schizophrenia. CYP2D6 genotype remarkably...

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PMID: 20599499
DOI: 10.1016/j.ejps.2010.06.016

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