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Article

Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients.

Human psychopharmacology - 1 Jan 2012

Suzuki Yutaro, Fukui Naoki, Tsuneyama Nobuto, Watanabe Junzo, Ono Shin, Sugai Takuro, Saito Mami, Inoue Yoshimasa, Someya Toshiyuki

Abstract excerpt

OBJECTIVE: The sum of the serum levels of risperidone (RIS) and 9-hydroxyrisperidone (9-OH-RIS), which is the active moiety serum level, could be important for estimating the clinical effects of RIS. However, there have been no consistent results reported about the relationship between cytochrome P450 (CYP) 2D6*10 allele and plasma 9-OH-RIS or active moiety levels. We investigated the effect of the number of...

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PMID: 22745940
DOI: 10.1002/hup.1260

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