Article
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008
Janas Michelle L, Hodson Daniel, Stamataki Zania, Hill Sue, Welch Katie, Gambardella Laure, Trotman Lloyd C, Pandolfi Pier Paolo, Vigorito Elena, Turner Martin
Abstract excerpt
Control of the intracellular levels of phosphatidylinositol-(3, 4, 5)-trisphosphate by PI3K and phosphatase and tensin homolog (PTEN) is essential for B cell development and differentiation. Deletion of the PI3K catalytic subunit p110delta leads to a severe reduction in B1 and marginal zone (MZ) B cells, whereas deletion of PTEN results in their expansion. We have examined the relationship between these two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.