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Article

On the road to immortality: hTERT upregulation in cancer cells

31 Mar 2004

Abstract excerpt

Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells acquire immortality by continuous telomere maintenance which is predominantly due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase). Recent findings have provided mechanistic insight into how oncogenic activation as well as derepression,...

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PMID: 15094035
DOI: 10.1016/s0014-5793(04)00356-4

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