Article
CYP2D6*10 alleles do not determine plasma fluvoxamine concentration/dose ratio in Japanese subjects.
European journal of clinical pharmacology - 1 Feb 2003
Ohara Koichi, Tanabu Shigeru, Ishibashi Kazuhisa, Ikemoto Keiko, Yoshida Kimiko, Shibuya Haruo
Abstract excerpt
OBJECTIVE: The purpose of the present study was to investigate whether plasma fluvoxamine (FV) concentration is associated with CYP2D6*10 allele polymorphisms. METHODS: Subjects were 46 Japanese patients (21 males) carrying neither *3, *4 nor *5 alleles and treated orally using FV. Venous blood was obtained from each patient for determination of FV concentration/dose (C/D) ratio (plasma concentration of FV...
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