Article
Dose-dependent effect of the CYP2D6 genotype on the steady-state fluvoxamine concentration.
Therapeutic drug monitoring - 1 Dec 2008
Watanabe Junzo, Suzuki Yutaro, Fukui Naoki, Sugai Takuro, Ono Shin, Inoue Yoshimasa, Someya Toshiyuki
Abstract excerpt
Several studies have reported that the cytochrome P450 (CYP) 2D6 plays an important role in the fluvoxamine metabolism. However, some other studies have reported that the CYP2D6 genotype has no major impact on the fluvoxamine concentration. This study investigated the dose-dependent effect of CYP...
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