Article
Effects of the CYP 2D6 genotype and cigarette smoking on the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients.
Therapeutic drug monitoring - 1 Aug 2003
Gerstenberg Gisa, Aoshima Toshiaki, Fukasawa Takashi, Yoshida Keizo, Takahashi Hitoshi, Higuchi Hisashi, Murata Yoshiko, Shimoyama Ritsuko, Ohkubo Tadashi, Shimizu Tetsuo, Otani Koichi
Abstract excerpt
The effects of the cytochrome P450 (CYP) 2D6 genotype and cigarette smoking on the steady-state plasma concentrations (C(ss)) of fluvoxamine (FLV) and its demethylated metabolite fluvoxamino acid (FLA) were studied in 49 Japanese depressed patients receiving FLV 200 mg/d. The C(ss) of FLV and FLA were measured by HPLC, and the wild-type allele (*1) and two mutated alleles causing absent (*5) or decreased (*10)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.