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Article

Asymmetric inheritance of oxidatively damaged proteins during cytokinesis.

Science (New York, N.Y.) - 14 Mar 2003

Aguilaniu Hugo, Gustafsson Lena, Rigoulet Michel, Nyström Thomas

Abstract excerpt

Carbonylated proteins were visualized in single cells of the budding yeast Saccharomyces cerevisiae, revealing that they accumulate with replicative age. Furthermore, carbonylated proteins were not inherited by daughter cells during cytokinesis. Mother cells of a yeast strain lacking the sir2 gene, a life-span determinant, failed to retain oxidatively damaged proteins during cytokinesis. These findings suggest...

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PMID: 12610228
DOI: 10.1126/science.1080418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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