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Article

Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing.

Biochimica et biophysica acta - 1 May 2010

Orlandi Ivan, Bettiga Maurizio, Alberghina Lilia, Nyström Thomas, Vai Marina

Abstract excerpt

Carbonylation of proteins is an irreversible oxidative damage that increases during both chronological and replicative yeast aging. In the latter, a spatial protein quality control system that relies on Sir2 is responsible for the asymmetrical damage segregation in the mother cells. Proper localization of Sir2 on chromatin depends on the deubiquitinating enzyme Ubp10, whose loss of function deeply affects the...

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PMID: 20211662
DOI: 10.1016/j.bbamcr.2010.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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