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Article

On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction.

Epidemiology (Cambridge, Mass.) - 1 Mar 2003

Yang Quanhe, Khoury Muin J, Friedman J M, Flanders W Dana

Abstract excerpt

Most methods for calculating the sample size needed to detect gene-environment interactions use odds ratios to measure the effect size. We show that for any combination of susceptible genotype prevalence and exposure prevalence and their associated risks, the odds ratio measuring strength of interaction corresponds to a population attributable fraction (PAF) because of interaction and vice versa. Simultaneous...

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PMID: 12606881
DOI: 10.1097/01.EDE.0000040256.22618.12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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