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Article

Population and familial relative risks of disease associated with environmental factors in the presence of gene-environment interaction.

American journal of epidemiology - 1 Jun 1993

Khoury M J, James L M

Abstract excerpt

With increasing availability of polymorphic DNA markers, family studies can be used to identify linked susceptibility genes for chronic diseases. Nevertheless, in the presence of gene-environment interaction, the ability of family studies to detect associations between exposures and diseases has not been adequately compared with population studies. The authors derive and compare exposure relative risk measures...

Topics

Alleles
Environmental Exposure
Family
Gene Frequency
Genes, Dominant
Genes, Recessive
Genetic Predisposition to Disease
Genotype
Humans
Models, Genetic
Risk Factors

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Identifiers

PMID: 8322764
DOI: 10.1093/oxfordjournals.aje.a116626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8322764-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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