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Article

Sample size needed to detect gene-gene interactions using association designs.

American journal of epidemiology - 1 Nov 2003

Wang Shuang, Zhao Hongyu

Abstract excerpt

It is likely that many complex diseases result from interactions among several genes, as well as environmental factors. The presence of such interactions poses challenges to investigators in identifying susceptibility genes, understanding biologic pathways, and predicting and controlling disease risks. Recently, Gauderman (Am J Epidemiol 2002;155:478-84) reported results from the first systematic analysis of the...

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PMID: 14585768
DOI: 10.1093/aje/kwg233

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