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Article

Minimum sample size estimation to detect gene-environment interaction in case-control designs.

American journal of epidemiology - 1 Dec 1994

Hwang S J, Beaty T H, Liang K Y, Coresh J, Khoury M J

Abstract excerpt

As genetic markers become more available, case-control studies will be increasingly important in defining the role of genetic factors in disease causality. The authors estimate the minimum sample size needed to assure adequate statistical power to detect gene-environment interaction. One assumption is made: the prevalence of exposure is independent of marker genotypes among controls. Given the assumption, six...

Topics

Case-Control Studies
Environment
Genetic Markers
Genotype
Humans
Odds Ratio
Research Design
Risk
Sample Size

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7985651
DOI: 10.1093/oxfordjournals.aje.a117193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7985651-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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