Article
Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.
The Journal of biological chemistry - 17 Jun 2011
Zhou Wei, Brush Matthew H, Choy Meng S, Shenolikar Shirish
Abstract excerpt
Stress-induced endogenous and ectopically expressed GADD34 proteins were present both in the cytoplasm and in membranes, with their membrane association showing similar biochemical properties. Deletion of N-terminal sequences in GADD34-GFP proteins highlighted an amphipathic helix, whose hydrophobic surface, specifically valine 25 and leucine 29, mediated endoplasmic reticulum (ER) localization. Substitution of...
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