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Coronavirus Infection Modulates the Unfolded Protein Response and Mediates Sustained Translational Repression

28 Feb 2008

Abstract excerpt

During coronavirus replication, viral proteins induce the formation of endoplasmic reticulum (ER)-derived double-membrane vesicles for RNA synthesis, and viral structural proteins assemble virions at the ER-Golgi intermediate compartment. We hypothesized that the association and intense utilization of the ER during viral replication would induce the cellular unfolded protein response (UPR), a signal transduction...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 18305036
DOI: 10.1128/jvi.00017-08

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