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Article

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.

The American journal of pathology - 1 Nov 2008

Lin Wensheng, Kunkler Phillip E, Harding Heather P, Ron David, Kraig Richard P, Popko Brian

Abstract excerpt

The T-cell-derived, pleiotropic cytokine interferon (IFN)-gamma is believed to play a key regulatory role in immune-mediated demyelinating disorders of the central nervous system, including multiple sclerosis and experimental autoimmune encephalomyelitis. Our previous work has demonstrated that the endoplasmic reticulum (ER) stress response modulates the response of oligodendrocytes to this cytokine. The ER...

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Identifiers

PMID: 18818381
DOI: 10.2353/ajpath.2008.080449
PMCID: PMC2570140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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