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Article

The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Lee Joon-Kyu, Seo Yeon-Soo, Hurwitz Jerard

Abstract excerpt

Previous studies in Saccharomyces cerevisiae have defined an essential role for the Dbf4-Cdc7 kinase complex in the initiation of DNA replication presumably by phosphorylation of target proteins, such as the minichromosome maintenance (Mcm) complex. We have examined the phosphorylation of the Mcm complex by the Dfp1-Hsk1 kinase, the Schizosaccharomyces pombe homologue of Dbf4-Cdc7. In vitro, the purified...

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Identifiers

PMID: 12604790
DOI: 10.1073/pnas.0237384100
PMCID: PMC151341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase.PMID 12604790Read ↗

Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast.Semantic proximity Read ↗

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Semantic proximity Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.Semantic proximity Read ↗

Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Semantic proximity Read ↗

Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.Semantic proximity Read ↗

Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.Semantic proximity Read ↗

Schizosaccharomyces pombe replication protein Cdc45/Sna41 requires Hsk1/Cdc7 and Rad4/Cut5 for chromatin binding.Semantic proximity Read ↗

Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain.Semantic proximity Read ↗

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4Semantic proximity Read ↗

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.Semantic proximity Read ↗

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.Semantic proximity Read ↗

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