Huntingtin interacts with a family of WW domain proteins.

doi:10.1093/hmg/7.9.1463

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Article

Huntingtin interacts with a family of WW domain proteins.

Human molecular genetics - 1 Sept 1998

Faber P W, Barnes G T, Srinidhi J, Chen J, Gusella J F, MacDonald M E

Abstract excerpt

The hallmark neuropathology of Huntington's disease (HD) is due to elongation of a polyglutamine segment in huntingtin, a novel approximately 350 kDa protein of unknown function. We used a yeast two-hybrid interactor screen to identify proteins whose association with huntingtin might be altered i...

Topics

Amino Acid Sequence
Binding Sites
Carrier Proteins
Gene Expression
Humans
Huntingtin Protein
Huntington Disease
In Vitro Techniques
Lymphocytes
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
Nuclear Proteins
RNA, Messenger
Saccharomyces cerevisiae
Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 9700202
DOI: 10.1093/hmg/7.9.1463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9700202-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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