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Article

A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum

1 Jun 2003

Abstract excerpt

At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by immunological measurements of IGF-I levels. However, immunoassays ignore the modifying effects of the IGF-binding proteins (IGFBPs) on the interaction between IGF-I and the IGF-I receptor (IGF-IR). Therefore, we developed an IGF-I kinase receptor activation assay (KIRA) based on cells transfected with the human IGF-IR...

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PMID: 12604504
DOI: 10.1152/ajpendo.00410.2002

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Source receipt: pubmed, retrieved 7 Sept 2026.

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