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Article

Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4.

Chemico-biological interactions - 1 Feb 2003

Belyaeva Olga V, Chetyrkin Sergei V, Kedishvili Natalia Y

Abstract excerpt

Human NAD(+)-dependent microsomal short-chain dehydrogenase/reductase RoDH-4 oxidizes all-trans-retinol, 13-cis-retinol and 3alpha-hydroxysteroids to corresponding retinaldehydes and 3-ketones. RoDH-4 behaves as an integral membrane protein, but its topology in the membrane is not known. Analysis of RoDH-4 polypeptide using algorithms for secondary structure predictions suggests that RoDH-4 contains four...

Topics

Alcohol Oxidoreductases
Animals
Base Sequence
Catalysis
DNA Primers
Humans
Microsomes
Mutation
Plasmids
Recombinant Proteins
Spodoptera
Subcellular Fractions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12604214
DOI: 10.1016/s0009-2797(02)00181-3

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