Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M.

Chemico-biological interactions - 30 May 2011

Lee Seung-Ah, Belyaeva Olga V, Kedishvili Natalia Y

Abstract excerpt

Retinol dehydrogenase 12 (RDH12) is a microsomal enzyme that catalyzes the reduction of all-trans-retinaldehyde to all-trans-retinol when expressed in cells. Mutations in RDH12 cause severe retinal degeneration; however, some of the disease-associated RDH12 mutants retain significant catalytic activity. Our previous study (Lee et al., 2010 [9]) demonstrated that the catalytically active T49M and I51N variants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dimethyl Sulfoxide

Share to Methylamines

Share to Molecular Weight

Share to Phenylbutyrates

Share to Protease Inhibitors

Share to Proteasome Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 21232531
DOI: 10.1016/j.cbi.2011.01.001
PMCID: PMC3086964

Genes

RDH12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M.PMID 21232531Read ↗

Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific rates.Semantic proximity Read ↗

Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies.Semantic proximity Read ↗

Rdh12 activity and effects on retinoid processing in the murine retina.Semantic proximity Read ↗

Focus on molecules: retinol dehydrogenase 12 (RDH12).Semantic proximity Read ↗

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.Semantic proximity Read ↗

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.Semantic proximity Read ↗

Redundant and unique roles of retinol dehydrogenases in the mouse retinaSemantic proximity Read ↗

Characterization of key residues and membrane association domains in retinol dehydrogenase 10.Semantic proximity Read ↗

Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus.Semantic proximity Read ↗

Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for retinitis pigmentosa.Semantic proximity Read ↗

Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.