Article
Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells.
The Journal of investigative dermatology - 1 Oct 1998
Cavani A, Mei D, Guerra E, Corinti S, Giani M, Pirrotta L, Puddu P, Girolomoni G
Abstract excerpt
To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals. CD4+ T cells purified from peripheral...
Topics
- Adult
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Division
- Dermatitis, Allergic Contact
- Dermatitis, Contact
- Female
- Humans
- Immunologic Memory
- Interferon-gamma
- Interleukin-10