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Article

Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations.

Hepatology (Baltimore, Md.) - 1 Mar 2003

Yamamoto Yoshiya, Sakamoto Michiie, Fujii Gen, Tsuiji Hitomi, Kenetaka Kengo, Asaka Masahiro, Hirohashi Setsuo

Abstract excerpt

To identify the genes responsible for carcinogenesis and progression of hepatocellular carcinoma (HCC), we screened differentially expressed genes in several human HCC cell lines. Among these genes, Gpr49 was up-regulated in PLC/PRF/5 and HepG2. Gpr49 is a member of the glycoprotein hormone receptor subfamily, which includes the thyroid-stimulating hormone receptor (TSHR). However, Gpr49 remains to be an orphan...

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Identifiers

PMID: 12601349
DOI: 10.1053/jhep.2003.50029

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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