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Article

Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.

Journal of the National Cancer Institute - 21 Nov 2007

Tao Qingguo, Fujimoto Junya, Men Taoyan, Ye Xiaofeng, Deng Jiong, Lacroix Ludovic, Clifford John L, Mao Li, Van Pelt Carolyn S, Lee J Jack, Lotan Dafna, Lotan Reuben

Abstract excerpt

BACKGROUND: Lung cancers develop via multiple genetic and epigenetic changes, including inactivation of tumor suppressor genes. We previously cloned human G protein-coupled receptor family C type 5A (GPRC5A), whose expression is suppressed in some human lung carcinoma cells, and its mouse homolog Gprc5a. METHODS: We generated Gprc5a knockout mice by homologous recombination and studied their phenotype by...

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PMID: 18000218
DOI: 10.1093/jnci/djm208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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