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Article

Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.

Toxicologic pathology - 1 Jan 2005

Hokaiwado Naomi, Asamoto Makoto, Ogawa Kumiko, Shirai Tomoyuki

Abstract excerpt

Much experimental evidence supports the conclusion that loss of gap junctional intercellular communication (GJIC) contributes to carcinogenesis. Transgenic rats featuring a dominant negative mutant of the connexin 32 gene under albumin promoter control (Cx32Delta Tg-High and Cx32Delta Tg-Low lines, respectively with high and low copy numbers of the transgene) have disrupted GJIC, as demonstrated by scrape...

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Identifiers

PMID: 16243774
DOI: 10.1080/01926230500330313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.PMID 16243774Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

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Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.Semantic proximity Read ↗

The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.Semantic proximity Read ↗

WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.Semantic proximity Read ↗

Role of connexin32 and beta-catenin in tumor promotion in mouse liver.Semantic proximity Read ↗

Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32.Semantic proximity Read ↗

Transgenic hepatocarcinogenesis in the rat.Semantic proximity Read ↗

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