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Article

Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R.

The Journal of biological chemistry - 1 Jan 2000

Avesani Anna, Marino Valerio, Zanzoni Serena, Koch Karl-Wilhelm, Dell'Orco Daniele

Abstract excerpt

In murine and bovine photoreceptors, guanylate cyclase-activating protein 2 (GCAP2) activates retinal guanylate cyclases (GCs) at low Ca2+ levels, thus contributing to the Ca2+/cGMP negative feedback on the cyclase together with its paralog guanylate cyclase-activating protein 1, which has the same function but different Ca2+ sensitivity. In humans, a GCAP2 missense mutation (G157R) has been associated with...

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Identifiers

PMID: 33812995
DOI: 10.1016/j.jbc.2021.100619
PMCID: PMC8113879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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