Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R.

The Journal of biological chemistry - 1 Jan 2000

Avesani Anna, Marino Valerio, Zanzoni Serena, Koch Karl-Wilhelm, Dell'Orco Daniele

Abstract excerpt

In murine and bovine photoreceptors, guanylate cyclase-activating protein 2 (GCAP2) activates retinal guanylate cyclases (GCs) at low Ca2+ levels, thus contributing to the Ca2+/cGMP negative feedback on the cyclase together with its paralog guanylate cyclase-activating protein 1, which has the same function but different Ca2+ sensitivity. In humans, a GCAP2 missense mutation (G157R) has been associated with...

Topics

Calcium
Guanylate Cyclase-Activating Proteins
Humans
Magnesium
Mutation
Protein Conformation
Protein Multimerization
Retinal Dystrophies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33812995
DOI: 10.1016/j.jbc.2021.100619
PMCID: PMC8113879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R.PMID 33812995Read ↗

Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.Semantic proximity Read ↗

Molecular Properties of Human Guanylate Cyclase-Activating Protein 3 (GCAP3) and Its Possible Association with Retinitis PigmentosaSemantic proximity Read ↗

A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase.Semantic proximity Read ↗

Dysfunction of cGMP signalling in photoreceptors by a macular dystrophy-related mutation in the calcium sensor GCAP1.Semantic proximity Read ↗

Supramolecular complexes of GCAP1: towards the development of effective biologics for inherited retinal dystrophiesSemantic proximity Read ↗

Neuronal Calcium Sensor GCAP1 Encoded by GUCA1A Exhibits Heterogeneous Functional Properties in Two Cases of Retinitis Pigmentosa.Semantic proximity Read ↗

Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.Semantic proximity Read ↗

Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).Semantic proximity Read ↗

Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase.Semantic proximity Read ↗

Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells.Semantic proximity Read ↗

Photoreceptor guanylate cyclase variants: cGMP production under control.Semantic proximity Read ↗

Molecular Characterization of a Third Member of the Guanylyl Cyclase-activating Protein SubfamilySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.