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Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.

Cellular and molecular life sciences : CMLS - 1 Mar 2010

Dell'Orco Daniele, Behnen Petra, Linse Sara, Koch Karl-Wilhelm

Abstract excerpt

Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca(2+) sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors. In this study, we investigated the Ca(2+)-induced effects on the conformation and the thermal stability of four GCAP1 variants associated with hereditary human cone dystrophies. Ca(2+) binding stabilized the conformation of all the...

Topics

Binding Sites
Calcium
Genetic Variation
Guanylate Cyclase
Guanylate Cyclase-Activating Proteins
Humans
Models, Molecular
Protein Conformation
Protein Stability
Retinitis Pigmentosa

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Identifiers

PMID: 20213926
DOI: 10.1007/s00018-009-0243-8
PMCID: PMC11115885

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Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.PMID 20213926Read ↗

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